ABSTRACT
A solitary fibrous tumour (SFT) is an unusual spindle cell neoplasm that usually occurs in the pleura but has recently been described in diverse extrapleural sites. Urogenital localisation is rare, and to our knowledge, only 82 cases of SFT of the kidney have been described. Although SFT of the kidney is extremely rare, this tumour must be included in the differential diagnosis, whenever a renal tumour consisting of mesenchymal elements is encountered. We report a case of a large SFT of the left kidney which was clinically and radiologically thought to be a renal cell carcinoma, and a final diagnosis was made after immunohistochemical study.
ABSTRACT
Papillary serous carcinomas of testis are very rare, and only case reports have been reported in the literature. These neoplasms are characterised histologically by papillary fronds and numerous psammoma bodies and exhibit immunoreactivity for markers of ovarian serous carcinomas. These are very aggressive and are both chemo and radioresistant with surgery remained the main stay of management.
ABSTRACT
Background: Thyroid cancer accounts for approximately 1% of total cancer cases Thyroid neoplasms are most common malignant lesions in endocrine system Their incidence is rapidly increasing in recent times, partially attributed to increased awareness and earlier detection of asymptomatic tumors They present clinically as nodular or diffuse mass lesions of thyroid similar to non- neoplastic lesions A wide spectrum of neoplasms is encountered and histopathology evaluation is crucial to establish diagnosis This study is done to present spectrum of thyroid neoplasms with varied histomorphology at a tertiary care center Aim: To study the spectrum of thyroid neoplasms at MNJ Institute of Oncology for over a period of one year with special mention of interesting cases and overview of diagnostic pitfalls encountered Materials and methods: All thyroidectomy specimens submitted to Department of Pathology for a period of one year, from October 2017 to September 2018 were included in study Routine processing and staining along with ancillary techniques where ever necessary were used to arrive at diagnosis Results: A total of 104 thyroidectomy specimens were included in the present study Thyroid cancer was common in females The most commonly encountered malignancy was Papillary carcinoma, seen in 30-40 years age group Anaplastic carcinoma was seen in 60-70 years age group Conclusion: Papillary carcinoma was most commonly encountered thyroid malignancy followed by medullary and anaplastic carcinoma Follicular adenoma was the most common benign neoplasm We have encountered almost the entire spectrum of thyroid neoplasms including the rare variants
ABSTRACT
Adenoid cystic carcinoma (ACC) is an uncommon tumour usually arise in the head and neck region mainly in the salivary gland and rare in the nose and para-nasal sinuses (PNS). We report a rare case of 35-year-old male with ACC of PNS who presented with nasal obstruction and nasal discharge. The CT PNS and orbits show illdefined minimally enhancing soft tissue density lesion extending into buccinators fossa, PNS, nasal cavity with adjacent bony destruction. Surgical incision was done and biopsy revealed ACC. Radiotherapy was given and regular follow-up done. The ACC of sinonasal cavities has poor prognosis, high recurrence due to peri-neural invasion. Multimodality treatment is the mainstay of ACC
ABSTRACT
Materials and methods Retrospective study for period of 2 years was conducted. For this study, we reviewed bone marrow material along with nodal and extranodal tissues. There were 16 cases of mantle cell lymphoma (MCL). Each patient had an absolute lymphocyte count of more than 10 × 109/l at the time of initial evaluation at our institution. Giemsa stained peripheral blood and bone marrow aspirate smears were reviewed, along with haematoxylin-eosin-stained histologic sections of bone marrow aspiration and core biopsy specimens. The immuno-phenotype of the neoplastic cells supported the diagnosis of MCL. The clinical and pathological spectrum will be discussed. Immuno-histochemistry Immuno-histochemical staining for CD3, CD20, CD23, CD1O, KI67 CYCLIN D1 were performed on formalin-fixed, paraffin-embedded tissue sections of either bone marrow aspirate or core biopsy tissue sections in all 16 cases. Results There were 11 men and 5 women with a median age of 68 years (range, 40–74 years). Physical examination revealed splenomegaly in 15 out of 16 patients. Lymphadenopathy involving multiple sites was present in 10 patients. Conclusion MCL can exhibit a wide spectrum of morphologic findings. We suggest that cell size and chromatin characteristics are useful for dividing these cases into two groups: small cell and large/blastoid. The large/blastoid group predicts poorer prognosis and includes cases with large cells, many of which are nucleolated and resemble prolymphocytes, as well as blastoid cells that resemble lymphoblasts. In this study, a cut-off of at least 20% large/blastoid cells best predicted poorer survival.
ABSTRACT
Epithelioid Trophoblastic Tumor (ETT) is a rare neoplasm of the chorionic type intermediate trophoblastic cells. It is a neoplasm of reproductive age women and usually follows a gestational event. ETT can occur at both intra uterine and extra uterine sites and can be confused with other entities such as squamous cell carcinoma, placental site nodule, placental site trophoblastic tumor etc. Hence, proper diagnosis of this tumor is necessary to avoid unnecessary, excessive treatment as surgical treatment is considered sufficient for ETT. We present a case of ETT in a 36 year old female, who came with symptoms of pain abdomen, white discharge per vaginum and a cervical mass.
ABSTRACT
A prospective study was undertaken on suspected lymph node TB (LNTB) patients, to evaluate the diagnostic utility of mycobacterial culture of fine needle aspirate (FNA), in comparison with the cytological examination and acid fast staining. Eighty percent of 157 aspirates studied were positive by cytological examination; 18% by ZN smear and 45% were positive by culture. Twelve aspirates which were negative by cytological features yielded positive mycobacterial cultures; four out of these were from HIV positive patients. Our observations suggest that supplementing FNA cytology with mycobacterial culture would increase the sensitivity of diagnosing LNTB; in addition to giving a highly specific diagnosis.